Johnny Isakson (born December 28, 1944, Atlanta, Georgia, U.S.—died December 19, 2021, Atlanta) was an American Republican politician who was a member of the U.S. Senate (2005–19). He previously served in the U.S. House of Representatives (1999–2005).
Isakson graduated from the University of Georgia in 1966. That year he entered the Georgia Air National Guard, and he served until 1972, leaving with the rank of staff sergeant. In 1967 he began working for a real-estate company, and he eventually became its president (1979–99). During that time Isakson married (1968), and he and his wife, Diane, had three children.
In 1974 Isakson ran for the Georgia House of Representatives and lost. Two years later, however, he was elected to the first of seven terms, and he eventually became the Republican minority leader (1983–90). After an unsuccessful bid (1990) for the governorship of Georgia, he was elected to the Georgia Senate, where he served from 1993 to 1996. That year he entered the U.S. Senate race but was defeated in the primary. When Newt Gingrich announced in 1998 that he was resigning from the U.S. House of Representatives, Isakson ran in a special election in 1999 and won. In 2004 he was elected to the Senate, and he took office the following year.
Isakson was widely regarded as a conservative. He took special interest in veterans affairs, assuming a leadership role in hearings surrounding the Veterans Access, Choice, and Accountability Act of 2014, which was passed to address the improprieties present in the management of Veterans Administration hospitals. He also was involved in international trade, notably seeking to strengthen the position of his home state as a trade partner, and he cosponsored legislation that would reform the federal budget process by converting it from an annual to a biannual basis, with the first year centring on appropriations and the second on spending oversight. On multiple occasions he also introduced legislation to revoke the charters of the Federal National Mortgage Corporation and Federal Home Loan Mortgage Corporation and replace them with a new federal finance agency.
In 2015 Isakson revealed that he had Parkinson disease. Citing health issues, he announced in 2019 that he would resign at the end of the year.