Guayama, town, southeastern Puerto Rico. It is situated on the divide between the Sierra de Cayey and the dry southern coastal plain. The town was founded in 1736 as San Antonio de Padua de Guayama. It produces clothing, furniture, and lenses. Chief crops of the surrounding area include tobacco, coffee, corn (maize), and fruits. Pop. (2000) 21,624; Guayama Metro Area, 83,570; (2010) 22,691; Guayama Metro Area, 84,214.