Khanty-Mansiysk, city and administrative centre of Khanty-Mansi autonomous okrug (district), Russia, in the West Siberian Plain. Situated on the Irtysh River near its confluence with the Ob River, the city was formed in 1950 from the urban settlement of Khanty-Mansiysk (founded 1931) and the village of Samarovo. Woodworking and fish-canning industries are important. Teacher-training and medical colleges are in the city. Pop. (2006 est.) 59,593.