Lárissa, town and dímos (municipality), Thessaly (Modern Greek: Thessalía) periféreia (region), central Greece. It is located on the Pineiós (also called Peneus) Potamós (river). Since the 9th century it has been the seat of a bishop.
In antiquity Lárissa was the seat of the Aleuad clan, founded by Aleuas, who claimed descent from Heracles. The poet Pindar and the physician Hippocrates, attracted by the Aleuad court, died there. In 480 bce the Aleuads supported the Persians. During the Peloponnesian War (431–404 bce), they supported Athens; thereafter the town was weakened by civil strife. In 357 bce the last Aleuads called in Philip II of Macedonia against the tyrants of Pherae, and from 344 to 196 Lárissa remained under Macedonia. Rome then made it capital of the reorganized Thessalian League.
The emperor Justinian fortified the town, the name of which means Citadel, but in 985 ce it fell to the Bulgars, and in 1204 it was occupied by the Franks of the Fourth Crusade. It was conquered by the Serbs in 1348 and in 1393 by the Turks, who held it until 1881, when Thessaly was annexed to the kingdom of Greece, beginning an exodus of Turkish residents, all of whom had left by the 1920s. In 1941 Lárissa was devastated by an earthquake, and it also suffered considerably during the German occupation (1941–44).
The centre of Thessaly’s thriving agricultural economy, Lárissa is in the midst of the Thessalian plain. The town produces high-quality ouzo (anise liqueur) and silk cloth; it has direct rail links to Vólos and Athens (Athína) and airport facilities. In the 1960s there was some industrial development, and there are large factories to manufacture sugar from locally grown sugar beet, as well as a paper-pulp plant. Pop. (2001) city, 131,095; municipality, 145,981; (2011) city, 144,651; municipality, 162,591.