Manzanillo, city and port, western Colima estado (state), west-central Mexico. It lies on the Pacific Ocean between Manzanillo Bay and Cuyutlán Lagoon. In pre-Columbian times the site was occupied by the town of Tzalahua, and ships for Hernán Cortés’s expedition (1533) to the Gulf of California were built there. The city’s commercial and manufacturing activities are based on the products from the farmlands, forests, and waters of Colima and part of neighbouring Jalisco state, which are gathered into and shipped from Manzanillo. The chief exports include copra, corn (maize), bananas, lemons, fish, minerals, lumber, wine, and canned goods. The beautiful beaches along Manzanillo Bay and Santiago Bay, north of the port, are tourist destinations, and many international resorts contribute to the local economy. Manzanillo is accessible by railroad and highway from Colima city, the state capital, to the northeast, and is served by domestic airlines. Pop. (2010) 130,035; (2020) 159,853.