Neustadt an der Weinstrasse, city, Rhineland-Palatinate Land (state), southwestern Germany. It lies on the eastern slope of the Haardt Mountains, where the Speyer River breaks through the Haardt into the Rhine River valley. Founded in 1220 and chartered in 1275, its historic buildings include the Casimirianum (the seat of Heidelberg University, 1578–83, now a convention hall), the town hall (formerly a Jesuit college), and the Stiftskirche (“Collegiate Church”), which is a Gothic abbey church dating from the 14th century.
Neustadt is the administrative centre of Rheinhessen-Pfalz district. The city is located in the Weinstrasse (“Wine Route”), the centre of the German wine trade. The Deutsche Weinlesefest (“Wine Festival”) is held annually in the city, which is also the site of a training and research institute of viticulture and horticulture. The city’s convenient location and picturesque setting at the foot of Mount Kalmit (2,208 feet [673 m]) make it a favourite tourist base. Its other economic activities include food processing and light manufacturing. Pop. (2005) 53,628.