Nsanje, town, southern Malawi, along the west bank of the Shire River and north of the Ndindi Marsh. It is home to the Manganja and Sena peoples, and as the country’s southernmost town, it serves as a customs post on the Mozambique border. It is also a trade and transportation centre on the north-south Blantyre-Beira railway (completed 1935). The surrounding area occupies the fertile western Shire valley; cotton, tobacco, rice, and corn (maize) are the chief products. Pop. (2008) 19,720.