Oyapock River, river that forms the border between French Guiana and the Brazilian state of Amapá. It rises in the Tumuc-Humac Mountains and flows northeast for 311 miles (500 km) to empty into the Atlantic near Cape Orange. The country through which it passes is thinly populated and is mostly covered by an unbroken tropical rain forest. Near the river’s mouth are the ports of Saint-Georges, French Guiana; and Oiapoque and Ponta dos Índios, Brazil.