Rubizhne, city, eastern Ukraine, on the Donets River. The settlement dates from the 18th century and was incorporated in 1934. Rubizhne has an engineering industry and, with Lysychansk and Syeverodonetsk, is one of the most important chemical centres in Ukraine. The city’s chemical industry dates from World War I, when it arose as a response to the industrialization of the Donets Basin coalfield. The city has various technical colleges. Pop. (2001) 65,322; (2005 est.) 63,474.