San Francisco, city, northeastern Córdoba provincia (province), north-central Argentina, on the border of Santa Fé province at the northern edge of the Pampa. Founded in 1886 and given city status in 1915, it has been a railroad centre since the 19th century and is a commercial and manufacturing centre for an agricultural (grain and flax) and pastoral area. Light manufacturing is important, as are dairy products and frozen meat. San Francisco is linked by railroad and highway to Córdoba, the provincial capital, and to Buenos Aires. Pop. (2001) 58,779.