Francis Willoughby, 5th Baron Willoughby (born c. 1613, England—died July 1666, at sea between Barbados and St. Kitts) was the governor of Barbados who in 1651 brought about the settlement of Suriname (then nominally Spanish territory) by immigrants from Caribbean and other South American colonies. Originally a supporter of Parliament in the English Civil War, he joined the Royalist side in 1648 and was appointed governor of Barbados by Charles II in 1650. He left Barbados in 1652, after the colony surrendered to a Cromwellian fleet. After the restoration of the monarchy, he was given joint proprietorship of Suriname with Lawrence Hyde.