Cristóbal de Castillejo (born 1490?, Ciudad Rodrigo, Spain—died probably June 12, 1550, Vienna) was a poet who was the foremost critic of the Italianate innovations of the Spanish poet Garcilaso de la Vega and the Catalan poet Juan Boscán.
While very young, Castillejo entered a monastery, but in 1525 he became the personal secretary to Ferdinand, brother of Charles I of Spain (Charles V of the Holy Roman Empire), and went to Vienna when Ferdinand became king of Austria.
One of the last Spanish poets to use the medieval octosyllabic line exclusively, he ruthlessly attacked the new Italianate metres introduced by his contemporaries, writing Contra los que dejan los metros castellanos y siguen los italianos (c. 1540; “Against Those Who Abandon Castilian Metres for Italian Ones”) in rhymed couplets. He championed the superiority of the traditional Spanish metre. He is also known for his erotic poetry, Sermón de amores (1542), which was suppressed in part by the Inquisition because of the levity with which it treated sacred texts.