Osler-Rendu-Weber disease

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Osler-Rendu-Weber disease

medical disorder

Also known as: Rendu-Osler-Weber disease, hemorrhagic telangiectasia, hereditary hemorrhagic telangiectasia

Written and fact-checked by The Editors of Encyclopaedia Britannica

Last Updated: Nov 10, 2024 • Article History

Also called:: hereditary hemorrhagic telangiectasia

Key People:: Sir William Osler, Baronet

Related Topics:: human cardiovascular system; capillary; blood vessel; purpura; familial disease

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News •

Key kinase involved in cell division linked to abnormal blood vessel growth in genetic disorder • Nov. 8, 2024, 6:06 AM ET (News-Medical)

Osler-Rendu-Weber disease, hereditary disorder characterized by bleeding from local capillary malformations. In Osler-Rendu-Weber disease, capillaries in the fingertips and around the oral and nasal cavities are enlarged and have unusually thin walls; they are easily broken by accidental bumping or jarring, resulting in the release of blood into the tissues or externally. Blood clotting is normal, but frequent bleeding from the nose and elsewhere can cause severe anemia. Frequent nosebleeds may be treated with cauterization or laser; bleeding in vital areas requires surgery.

This article was most recently revised and updated by Robert Curley.