hypothetico-deductive method, procedure for the construction of a scientific theory that will account for results obtained through direct observation and experimentation and that will, through inference, predict further effects that can then be verified or disproved by empirical evidence derived from other experiments.

An early version of the hypothetico-deductive method was proposed by the Dutch physicist Christiaan Huygens (1629–95). The method generally assumes that properly formed theories are conjectures intended to explain a set of observable data. These hypotheses, however, cannot be conclusively established until the consequences that logically follow from them are verified through additional observations and experiments. The method treats theory as a deductive system in which particular empirical phenomena are explained by relating them back to general principles and definitions. However, it rejects the claim of Cartesian mechanics that those principles and definitions are self-evident and valid; it assumes that their validity is determined only by the exact light their consequences throw on previously unexplained phenomena or on actual scientific problems.