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insulin-like growth factor 1
biochemistry
Also known as: IGF-1, somatomedin
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characteristics
- In insulin-like growth factor
There are two IGFs: IGF-1 and IGF-2. These two factors, despite the similarity of their names, are distinguishable in terms of specific actions on tissues because they bind to and activate different receptors. The major action of IGFs is on cell growth. Indeed, most of the actions of pituitary…
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stimulation by growth hormone
- In growth hormone
…release insulin-like growth factors, primarily insulin-like growth factor 1 (IGF-1; formerly called somatomedin). The term insulin-like growth factor is derived from the ability of high concentrations of these factors to mimic the action of insulin, although their primary action is to stimulate growth. Serum IGF-1 concentrations increase progressively with age…
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