Ask the Chatbot Games & Quizzes ProCon History & Society Science & Tech Biographies Animals & Nature Geography & Travel Arts & Culture Money Videos
metalation
Table of Contents
Introduction References & Edit History Related Topics
Read Next
Products from aluminum, copper, bronze, and brass on a white background. (metals)
Why Are Some Metals More Conductive than Others?
Chemical equations Chemical reactions chemistry
How Do You Balance a Chemical Equation?
Illustration of molecules. (molecular, chemistry, science)
Why Is a Group of Molecules Called a Mole?
Discover
Close up of books. Stack of books, pile of books, literature, reading. Homepage 2010, arts and entertainment, history and society
12 Novels Considered the “Greatest Book Ever Written”
Mayer Amschel Rothschild (1744-1855), founder of the house of Rothschild; lithograph by Friedrich Lieder, c. 1830.
Where Do Anti-Semitic Conspiracy Theories About the Rothschild Family Come From?
Baseball laying in the grass. Homepage blog 2010, arts and entertainment, history and society, sports and games athletics
10 Greatest Baseball Players of All Time
A human Inuit skull in a stone chambered cairn in Ilulissat in Greenland. These ancient graves are pre christian and are at least 2000
14 Tough Questions Answered
Thanksgiving Celebration Traditional Dinner Setting Food Concept
Why Is Thanksgiving in the U.S. Celebrated on a Thursday?
Santa Claus flying in his sleigh, christmas, reindeer
Was Santa Claus a Real Person?
The Cheshire Cat is a fictional cat from Lewis Carroll's Alice's Adventures in Wonderland. (Alice in Wonderland)
11 Banned Books Through Time

metalation

chemical process
verifiedCite
While every effort has been made to follow citation style rules, there may be some discrepancies. Please refer to the appropriate style manual or other sources if you have any questions.
Select Citation Style
Share
Share to social media
URL
https://www.britannica.com/science/metalation
Feedback
Corrections? Updates? Omissions? Let us know if you have suggestions to improve this article (requires login).
Thank you for your feedback

Our editors will review what you’ve submitted and determine whether to revise the article.

External Websites
Written and fact-checked by
The Editors of Encyclopaedia Britannica
Encyclopaedia Britannica's editors oversee subject areas in which they have extensive knowledge, whether from years of experience gained by working on that content or via study for an advanced degree. They write new content and verify and edit content received from contributors.
The Editors of Encyclopaedia Britannica
Article History

metalation, any chemical process by which a metal atom is introduced into an organic molecule to form an organometallic compound, but more commonly the process involving a hydrogen–metal exchange. An example is the metalation of benzene (C6H6) by reaction with ethylsodium (C2H5Na), forming phenylsodium (C6H5Na) and ethane (C2H6). Metalation by means of hydrogen–metal exchange is a very powerful method of removing a hydrogen atom (in the form of its cation, H+) from a chemical compound; the reaction, therefore, is useful in studying the relative acidities of such extremely weak acids as the hydrocarbons.