Skin

Radiation can cause various types of injury to the skin, depending on the dose and conditions of exposure. The earliest outward reaction of the skin is transitory reddening (erythema) of the exposed area, which may appear within hours after a dose of 6 Gy or more. This reaction typically lasts only a few hours and is followed two to four weeks later by one or more waves of deeper and more prolonged reddening in the same area. A larger dose may cause subsequent blistering and ulceration of the skin and loss of hair, followed by abnormal pigmentation months or years later.

Bone marrow

The blood-forming cells of the bone marrow are among the most radiosensitive cells in the body. If a large percentage of such cells are killed, as can happen when intensive irradiation of the whole body occurs, the normal replacement of circulating blood cells is impaired. As a result, the blood cell count may become depressed and, ultimately, infection, hemorrhage, or both may ensue. A dose below 0.5–1 Sv generally causes only a mild, transitory depletion of blood-forming cells; however, a dose above 8 Sv delivered rapidly to the whole body usually causes a fatal depression of blood-cell formation.

Gastrointestinal tract

The response of the gastrointestinal tract is comparable in many respects to that of the skin. Proliferating cells in the mucous membrane that lines the tract are easily killed by irradiation, resulting in the denudation and ulceration of the mucous membrane. If a substantial portion of the small intestine is exposed rapidly to a dose in excess of 10 Gy, as may occur in a radiation accident, a fatal dysentery-like reaction results within a very short period of time.

Reproductive organs

Although mature spermatozoa are relatively resistant to radiation, immature sperm-forming cells (spermatogonia) are among the most radiosensitive cells in the body. Hence, rapid exposure of both testes to a dose as low as 0.15 Sv may interrupt sperm-production temporarily, and a dose in excess of 4 Sv may be sufficient to cause permanent sterility in a certain percentage of men.

In the human ovary, oocytes of intermediate maturity are more radiosensitive than those of greater or lesser maturity. A dose of 1.5–2.0 Sv delivered rapidly to both ovaries may thus cause only temporary sterility, whereas a dose exceeding 2–3 Sv is likely to cause permanent sterility in an appreciable percentage of women.

Lens of the eye

Irradiation can cause opacification of the lens, the severity of which increases with the dose. The effect may not become evident, however, until many months after exposure. During the 1940s, some physicists who worked with the early cyclotrons developed cataracts as a result of occupational neutron irradiation, indicating for the first time the high relative biologic effectiveness of neutrons for causing lens damage. The threshold for a progressive, vision-impairing opacity, or cataract, varies from 5 Sv delivered to the lens in a single exposure to as much as 14 Sv delivered in multiple exposures over a period of months.

Brain and sensory organs

Generally speaking, humans do not sense a moderate radiation field; however, small doses of radiation (less than 0.01 Gy) can produce phosphene, a light sensation on the dark-adapted retina. American astronauts on the first spacecraft that landed on the Moon (Apollo 11, July 20, 1969) observed irregular light flashes and streaks during their flight, which probably resulted from single heavy cosmic-ray particles striking the retina. In various food-preference tests, rats, when given the choice, avoid radiation fields of even a few mGy. A dose of 0.03 Gy is sufficient to arouse a slumbering rat, probably through effects on the olfactory system, and a dose of the same order of magnitude can accelerate seizures in genetically susceptible mice. The mature brain and nervous system are relatively resistant to radiation injury, but the developing brain is radiosensitive to damage (see below).