The final stages

In October 2014 WHO declared Senegal and Nigeria to be free of Ebola, marking the end of the outbreak in those countries. Senegal had experienced only a single case, while 20—8 of which ended in death—had been reported in Nigeria. A small number of cases were also reported in Mali in October and November. Also in October, the number of cases confirmed weekly in Liberia began to decline rapidly. By mid-February 2015, dozens of schools in the country were reopened, having been closed for six months as part of the effort to prevent the spread of Ebola. Liberia was on the verge of being Ebola-free in March, but a new case emerged late that month, indicating that the outbreak was not yet over there. The country was declared to be free of the disease in early May, but in the following month a new case was detected. In early September the country again cleared the required 42-day waiting period from the last negative test, indicating the end of Ebola transmission there. However, the disease reemerged for a second time in November. Liberia finally was declared Ebola-free in January 2016.

In Guinea and Sierra Leone, case numbers had started to drop steeply in December 2014 but by early February the following year were on the rise again in both countries. In Guinea, community resistance continued to challenge aid efforts, furthering concerns about unsafe burials and unknown chains of disease transmission. By late July, however, the number of new cases diagnosed in Guinea had declined significantly. In Sierra Leone the situation had also improved, and that country finally was declared Ebola-free in early November. Guinea was declared free of the disease by the end of the following month.

By mid-January 2016 all known chains of Ebola transmission had come to an end in western Africa. WHO warned, however, that the risk of sudden outbreaks in the region remained high because of the persistence of the virus in survivors. Indeed, no sooner had WHO released the warning than a case of Ebola was reported in Sierra Leone. Later in the year, after the outbreak had ended, researchers collected blood samples from people in a small village in Sierra Leone and found that as many as 25 percent of Ebola-infected individuals there had been asymptomatic. The findings suggested that the outbreak may have been more widespread than previously thought. The overall fatality rate of the 2014–16 Ebola outbreak was estimated at between 50 and 70 percent.

Experimental treatments

At the beginning of August, an experimental antibody therapy known as ZMapp was administered to two American missionary workers in Liberia. Both patients were transported back to the United States following treatment, and both recovered, though it was unclear whether their recovery was a result of ZMapp. Nevertheless, ZMapp raised the possibility of using untested treatments in Ebola patients, which WHO officials subsequently endorsed. The organization provided guiding ethical criteria for the use of experimental treatments during the outbreak, but important questions remained, including how treatments in short supply would be distributed fairly. WHO also recommended prioritization of the use of transfusion of blood or plasma from recovered Ebola patients. By December, clinical trials were under way in the outbreak zone to investigate the safety and effectiveness of transfusions with convalescent blood or plasma, to improve the safety of such transfusions, and to test antiviral drugs.