During the reign of the Han emperor Wudi (141–87 bce), the wall was strengthened as part of an overall campaign against the Xiongnu. From that period the Great Wall also contributed to the exploitation of farmland in northern and western China and to the growth of the trade route that came to be known as the Silk Road. In 121 bce a 20-year project of construction was started on the Hexi Wall (generally known as the Side Wall) between Yongdeng (now in Gansu) in the east and Lake Lop Nur (now in Xinjiang) in the west. According to Juyan Hanjian (“Juyan Correspondence of the Han”), the strongpoints set up along the wall included “a beacon every 5 li, a tower every 10 li, a fort every 30 li, and a castle every 100 li.”

The main work on the wall during the Dong (Eastern) Han period (25–220 ce) took place during the reign of Liu Xiu (Guangwudi), who in 38 ordered the repair of four parallel lines of the Great Wall in the area south of the Hexi Wall. The Great Wall served not only for defense but also to centralize control of trade and travel.

During the Bei (Northern) Wei dynasty (386–534/535 ce), the Great Wall was repaired and extended as a defense against attacks from the Juan-juan and Khitan tribes in the north. According to Wei shu: Mingyuandi Ji (“History of Wei: Chronicle of Emperor Mingyuan”), in 417, the eighth year of the reign of Mingyuandi (409–423), a part of the Great Wall was built south of Changchuan, from Chicheng (now in Hebei) to Wuyuan (now in Inner Mongolia) in the west, extending more than 620 miles (1,000 km). During the reign of Taiwudi (423–452), a lower and thinner wall of rammed earth was built around the capital as a complement to the Great Wall. Starting from Guangling in the east, it extended to the eastern side of the Huang He, forming a circle around Datong. In 549, after the Dong Wei kingdom moved its capital east to Ye, it also built a segment of the Great Wall in the area of contemporary Shanxi province.

In order to strengthen its northern frontier and prevent invasion from the west by the Bei Zhou, the Bei Qi kingdom (550–577) launched several big construction projects that were nearly as extensive in scope as the building projects of the Qin dynasty. In 552 a segment was built on the northwestern border, and only three years later the emperor ordered the recruitment of 1.8 million workers to repair and extend other sections. The construction took place between the south entrance of Juyong Pass (near modern Beijing) and Datong (in Shanxi). In 556 a new fortification was set up in the east and extended to the Yellow Sea. The following year a second wall was built inside the Great Wall within modern Shanxi, beginning in the vicinity of Laoying east of Pianguan, extending to the east beyond Yanmen Pass and Pingxing Pass, and ending in the area around Xiaguan in Shanxi. In 563 the emperor Wuchengdi of the Bei Qi had a segment repaired along the Taihang Mountains. That is the part of the Great Wall found today in the area around Longguan, Guangchang, and Fuping (in Shanxi and Hebei). In 565 the inner wall built in 557 was repaired, and a new wall was added that started in the vicinity of Xiaguan, extended to the Juyong Pass in the east, and then joined to the outer wall. The segments repaired and added during the Bei Qi period totaled some 900 miles (1,500 km), and towns and barracks were established at periodic intervals to garrison the new sections. In 579, in order to prevent invasions of the Bei Zhou kingdom by the Tujue (a group of eastern Turks) and the Khitan, the emperor Jing started a massive rebuilding program on areas of the wall located in the former Bei Qi kingdom, starting at Yanmen in the west and ending at Jieshi in the east.

During the Sui dynasty (581–618) the Great Wall was repaired and improved seven times in an effort to defend the country against attacks from the Tujue. After the Tang dynasty (618–907) replaced the Sui, the country grew much stronger militarily, defeating the Tujue in the north and expanding beyond the original frontier. Thus, the Great Wall gradually lost its significance as a fortification, and there was no need for repairs or additions. During the Song dynasty (960–1279), however, the Liao and Jin peoples in the north were a constant threat. The Song rulers were forced to withdraw to the south of the lines of the Great Wall built by the Qin, Han, and Northern dynasties. Many areas on both sides of the wall were subsequently taken over by the Liao (907–1125) and Jin dynasties (1115–1234). When the Song rulers had to retreat even farther—to the south of the Yangtze River (Chang Jiang)—repairs to the wall or extensions of it were no longer feasible. Limited repairs were carried out once (1056) during Liao times but only in the area between the Yazi and Huntong rivers.

In 1115, after the Jin dynasty was established, work was performed on two defensive lines at Mingchang. The old wall there—previously called the Wushu Wall, or Jinyuan Fort—ran westward from a point north of Wulanhada, then wound through the Hailatu Mountains, turning to the north and then to the west again, finally ending at the Nuanshui River. The second of the lines was the new Mingchang Wall, also called the Inner Jin Wall or the Jin Trench, which was constructed south of the old wall. It started in the west from a bend in the Huang He and ended at the Sungari (Songhua) River.

During the Yuan (Mongol) dynasty (1206–1368), the Mongols controlled all of China, as well as other parts of Asia and sections of Europe. As a defensive structure the Great Wall was of little significance to them; however, some forts and key areas were repaired and garrisoned in order to control commerce and to limit the threat of rebellions from the Chinese (Han) and other nationalities.