Alfred G. Gilman

Alfred G. Gilman (born July 1, 1941, New Haven, Connecticut, U.S.—died December 23, 2015, Dallas, Texas) was an American pharmacologist who shared the 1994 Nobel Prize for Physiology or Medicine with American biochemist Martin Rodbell for their separate research in discovering molecules called G proteins. These are intermediaries in the multistep pathway cells use to react to an incoming signal, such as a hormone or neurotransmitter.

Gilman attended Yale University (B.S., 1962) and Case Western Reserve University (M.D. and Ph.D., 1969), where he studied under Nobel Prize recipient Earl W. Sutherland, Jr. Following three years of postdoctoral research at the National Institutes of Health, Gilman took a position as a pharmacology professor at the University of Virginia, where he conducted his seminal research. In 1981 he became chairman of the pharmacology department at the University of Texas Southwestern Medical Center’s medical school in Dallas, where he was elected executive vice president for academic affairs and provost in 2006. Three years later he left to become chief scientific officer of the Cancer Prevention and Research Institute of Texas (2009–12).

In the 1960s Rodbell demonstrated that a cell’s response to a chemical signal involves not only a receptor for the signal at the cell’s surface and an amplifier that functions within the cell, as was already known, but also an intermediary molecule that transduces, or relays, the message from receptor to amplifier. Gilman, working in the 1970s with mutant cells that were unable to send signals properly, identified the intermediary signaling molecule as a G protein, so named because it becomes activated when bound to a molecule called guanosine triphosphate (GTP). Abnormally functioning G proteins can disrupt the normal signal transduction process and play a role in diseases such as cholera, cancer, and diabetes.

Gilman edited several editions of Goodman and Gilman’s The Pharmacological Basis of Therapeutics, one of the most-respected works in the field of pharmacology; Gilman’s father cowrote the first edition, which was published in 1941. In addition to the Nobel Prize, Gilman was the recipient of numerous honours. Notably, he became a member of the National Academy of Sciences in 1985, and he was a 1989 recipient of the Lasker Award for basic medical research.