North of the trading post at Wrigley, the Redstone and Keele rivers enter from the west; they have deep canyons where they break out of the Mackenzie Mountains but flow across the lowland as shallow, braided streams. These rivers and the others that drain from the Mackenzie Mountains have their peak flows in June after the snow melts in the mountains and become shallow rivers in late summer. The Mackenzie River picks up relatively little volume within its valley lowland, as the average summer precipitation recorded at dispersed settlements is only about 7 or 8 inches (175 to 200 mm); total annual precipitation throughout the Mackenzie valley is 10 to 14 inches (250 to 355 mm).

At the village of Fort Norman the cold, clear water of the Great Bear River enters from the east. This short river empties out of Great Bear Lake and is navigable for shallow-draft vessels, except for a short portage around rapids about 30 miles (50 km) east of its mouth. Once more, there is a distinct summer demarcation for 50 miles (80 km) northward in the Mackenzie River between its silt-laden water and the clear water from the Great Bear River on the eastern bank. At Norman Wells the Mackenzie River broadens to about 4 miles (6.4 km) in width and is less than 175 feet (53 metres) above sea level. The mean annual discharge of the river there is 302,000 cubic feet (8,550 cubic metres) per second, but flows during the summer months usually will average 460,000 cubic feet (13,030 cubic metres) per second.

The Mackenzie Lowland is only about 30 miles wide in this section, being broken by the treeless summits of the Franklin Mountains, which rise to elevations of little more than 3,000 feet (900 metres) on the east side of the river. Small lakes are not so common across the Mackenzie valley in this area as they are on the lowland west of Great Slave Lake. Forest vegetation is scanty except in the river valleys and in areas of better drainage; most of the trees are stunted spruce.

Where the Mountain River joins the Mackenzie from the west there is a fast-water section known as Sans Sault Rapids; the river drops about 20 feet (6 metres) within a few miles. There is ample depth of water for the shallow-draft barges during July, but, despite deepening of the channel by rock blasting, shallow water is sometimes a navigation problem in late summer. South of the Indian village of Fort Good Hope, the Mackenzie narrows as it flows between 100- to 150-foot (30- to 45-metre) perpendicular limestone cliffs known as The Ramparts. North of Fort Good Hope, the Mackenzie crosses the Arctic Circle. It is slightly entrenched and meanders across its flat valley floor, its banks being 2 to 3 miles (3.2 to 4.8 km) apart; low islands are numerous, and shifting sandbars are a problem for the riverboats. Where the Arctic Red River enters from the south, the Mackenzie again flows between steep rock walls, which rise up to 200 feet (60 metres) directly from the water.

The delta region

The Mackenzie River delta begins at Point Separation. The mean annual discharge of Mackenzie water into the delta, measured at the confluence of the Arctic Red River, is 340,000 cubic feet (9,630 cubic metres) per second, increasing to an average of 540,000 cubic feet (15,290 cubic metres) per second in summer. From the south the Peel River is the last major tributary of the Mackenzie, although it actually flows into the Mackenzie delta to the west of Point Separation. The delta covers about 4,700 square miles (12,170 square km) and is a maze of branching, intertwining channels, numerous cutoff lakes, and circular ponds. These lakes are an excellent habitat for muskrat, and the trapping of these animals became the main source of income for the Indian and Inuit (Eskimo) inhabitants of the delta in the period 1920–60.

The perpetually frozen subsurface known as permafrost lies a few feet beneath the surface of the islands in the delta and exists discontinuously beneath the entire Mackenzie Lowlands north of Great Slave Lake. Depending on the type of vegetation cover, the top few inches to several feet of ground above the permafrost thaws during the summer months. Northern construction of airfields, roads, and pipelines has to be adapted to these permafrost conditions; houses and other buildings are usually placed on wooden piles that are sunk and frozen into the permafrost for stability. One of the distinctive features of the town of Inuvik is a utilidor, a linear boxlike metal container raised slightly above the surface of the ground, in which the separate sewer, water, and heating pipes are placed. Mackenzie River water-transport routes terminate at Tuktoyaktuk on the Arctic coast northeast of the delta; there cargo is transferred to other vessels of greater draft, which serve the small settlements, radar stations, and oil-exploration sites along the western Arctic coast.