Grignard reaction

chemistry

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development

  • Victor Grignard.
    In Victor Grignard

    …for his development of the Grignard reaction. This work in organomagnesium compounds opened a broad area of organic synthesis.

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Grignard reagents

  • Synthetic applications of highly reactive organometallic reagents such as alkyllithium (LiR) and Grignard (RMgX). Sulfoxides (R2SO), for example, are prepared by treating thionyl chloride (SOCl2) with a Grignard reagent.
    In Grignard reagent

    Grignard reagents commonly are prepared by reaction of an organohalogen with magnesium in a nitrogen atmosphere because the reagent is very reactive toward oxygen and moisture. Organohalogens vary greatly in their rates of reaction with magnesium. For example, alkyl iodides generally react very rapidly, whereas…

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Key People:
Victor Grignard

Grignard reagent, any of numerous organic derivatives of magnesium (Mg) commonly represented by the general formula RMgX (in which R is a hydrocarbon radical: CH3, C2H5, C6H5, etc.; and X is a halogen atom, usually chlorine, bromine, or iodine). They are called Grignard reagents after their discoverer, French chemist Victor Grignard, who was a corecipient of the 1912 Nobel Prize for Chemistry for this work.

Grignard reagents commonly are prepared by reaction of an organohalogen with magnesium in a nitrogen atmosphere because the reagent is very reactive toward oxygen and moisture. Organohalogens vary greatly in their rates of reaction with magnesium. For example, alkyl iodides generally react very rapidly, whereas most aryl chlorides react very slowly, if at all.

Their chemical behaviour resembles that of carbanions, species that contain a negatively charged carbon. Grignard reagents are strong bases and strong nucleophiles. Thus, the Grignard reagent methylmagnesium bromide (CH3MgBr) behaves as if it were equivalent to the methide ion (CH3).

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More From Britannica
alcohol: Using Grignard and organolithium reagents

Except for hydrocarbons, ethers, and tertiary amines, almost all organic compounds react with Grignard reagents. Many of these reactions are used for synthetic purposes, notably those with carbonyl compounds (e.g., aldehydes, ketones, esters, and acyl chlorides), with epoxides, and with halogen compounds of certain metals (e.g., zinc, cadmium, lead, mercury) to form the alkyl derivatives of those metals.

Francis A. Carey