acetophenetidin

…major metabolite of acetanilid and phenacetin, which were once commonly used drugs, and is responsible for their analgesic (pain-relieving) effects. Acetaminophen relieves pain by raising the body’s pain threshold, and it reduces fever by its action on the temperature-regulating centre of the brain. The drug inhibits prostaglandin synthesis in the…

…replaced by the less toxic phenacetin. In 1899 aspirin (acetylsalicylic acid) became the most effective and popular anti-inflammatory, analgesic-antipyretic drug for at least the next 60 years. Cocaine, derived from the coca leaf, was the only known local anesthetic until about 1900, when the synthetic compound benzocaine was introduced. Benzocaine…

…can also be converted to acetophenetidin (also known as phenacetin), an analgesic.