cellular respiration

Glycolysis

Glycolysis (which is also known as the glycolytic pathway or the Embden-Meyerhof-Parnas pathway) is a sequence of 10 chemical reactions taking place in most cells that breaks down a glucose molecule into two pyruvate (pyruvic acid) molecules. Energy released during the breakdown of glucose and other organic fuel molecules from carbohydrates, fats, and proteins during glycolysis is captured and stored in ATP. In addition, the compound nicotinamide adenine dinucleotide (NAD⁺) is converted to NADH during this step (see below). Pyruvate molecules produced during glycolysis then enter the mitochondria, where they are each converted into a compound known as acetyl coenzyme A, which then enters the TCA cycle. (Some sources consider the conversion of pyruvate into acetyl coenzyme A as a distinct step, called pyruvate oxidation or the transition reaction, in the process of cellular respiration.)

Tricarboxylic acid cycle

The TCA cycle (which is also known as the Krebs, or citric acid, cycle) plays a central role in the breakdown, or catabolism, of organic fuel molecules. The cycle is made up of eight steps catalyzed by eight different enzymes that produce energy at several different stages. Most of the energy obtained from the TCA cycle, however, is captured by the compounds NAD⁺ and flavin adenine dinucleotide (FAD) and converted later to ATP. The products of a single turn of the TCA cycle consist of three NAD⁺ molecules, which are reduced (through the process of adding hydrogen, H⁺) to the same number of NADH molecules, and one FAD molecule, which is similarly reduced to a single FADH₂ molecule. These molecules go on to fuel the third stage of cellular respiration, whereas carbon dioxide, which is also produced by the TCA cycle, is released as a waste product.

Oxidative phosphorylation

In the oxidative phosphorylation stage, each pair of hydrogen atoms removed from NADH and FADH₂ provides a pair of electrons that—through the action of a series of iron-containing hemoproteins, the cytochromes—eventually reduces one atom of oxygen to form water. In 1951 it was discovered that the transfer of one pair of electrons to oxygen results in the formation of three molecules of ATP.

Oxidative phosphorylation is the major mechanism by which the large amounts of energy in foodstuffs are conserved and made available to the cell. The series of steps by which electrons flow to oxygen permits a gradual lowering of the energy of the electrons. This part of the oxidative phosphorylation stage is sometimes called the electron transport chain. Some descriptions of cellular respiration that focus on the importance of the electron transport chain have changed the name of the oxidative phosphorylation stage to the electron transport chain.

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