pyrimidine dimer

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pyrimidine dimer

chemical structure

Learn about this topic in these articles:

genetic disease

In human genetic disease: Ultraviolet radiation
Such pyrimidine dimerization is mutagenic, but this damage can be repaired by an enzyme called photolyase, which utilizes the energy of longer wavelengths of light to cleave the dimers. However, people with a defect in the gene coding for photolyase develop xeroderma pigmentosum, a condition characterized…
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UV-induced cancer

In cancer: Ultraviolet radiation
If a pyrimidine dimer in a growth regulatory gene is not immediately repaired, it can contribute to tumour development (see the section The molecular basis of cancer: DNA repair defects).
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