epidermis, in botany, outermost, protoderm-derived layer of cells covering the stem, root, leaf, flower, fruit, and seed parts of a plant. The epidermis and its waxy cuticle provide a protective barrier against mechanical injury, water loss, and infection. Various modified epidermal cells regulate

epidermis, in zoology, protective outermost portion of the skin. There are two layers of epidermis, the living basal layer, which is next to the dermis, and the external stratum corneum, or horny layer, which is composed of dead, keratin-filled cells that have migrated outward from the basal layer.

epithelioma: …include basal cell carcinoma and squamous cell carcinoma (cancerous epitheliomas are known as carcinomas), two types of skin cancer that involve the inner layers and scalelike outer cells of the skin, respectively; and parathyroid adenoma, a benign tumour of glandular tissue in the parathyroid gland that can cause a condition…

skin disease: Distribution: …hereditary blistering disorders collectively called epidermolysis bullosa owe their distributions to local trauma; lesions that show a predilection for the elbows, knees, and lower back are common in psoriasis, and those found in the hands, feet, knees, and mouth of children are indicative of epidermolysis bullosa. A lesion of an…

epididyme, either of a pair of elongated crescent-shaped structures attached to each of the two male reproductive organs, the testes (see testis). Sperm cells produced in the testes are transported to the epididymes, where they mature and are stored. Each epididymis has three regions, called,

epididyme, either of a pair of elongated crescent-shaped structures attached to each of the two male reproductive organs, the testes (see testis). Sperm cells produced in the testes are transported to the epididymes, where they mature and are stored. Each epididymis has three regions, called,

epididymitis, inflammation of the epididymis, the cordlike structure that runs along the posterior of the testis (testicle) and contains spermatozoa. In young men, epididymitis is most often caused by sexually transmitted agents such as Chlamydia and gonococcus, while in older men it is more likely

epidote, any of a group of colourless to green or yellow-green silicate minerals with the general chemical formula A2B3(SiO4)(Si2O7)O(OH), in which A is usually calcium (Ca), though manganese (Mn) or cerium (Ce) is sometimes substituted, and B is generally aluminum (Al), with the main substitution

epidote: Structurally, the epidote group consists of chains of AlO6 and Al4(OH)2 octahedra linked by independent SiO4 and Si2O7 groups. The A atoms are in eightfold coordination between the chains. Members of the epidote group include epidote (A = Ca, B = Al,Fe), clinozoisite (A = Ca, B…

epidote-amphibolite facies, one of the major divisions of the mineral-facies classification of metamorphic rocks, the rocks of which form under moderate temperature and pressure conditions (250°–400° C [500°–750° F] and up to 4 kilobars [1 kilobar equals about 15,000 pounds per square inch]). This

therapeutics: Local drug therapy: Spinal anesthesia and epidural anesthesia, in which a local anesthetic is injected into the subarachnoid or epidural space of the lumbar (lower back) area of the spinal canal, provide pain relief during childbirth or surgery that involves the pelvic area yet lack the problems associated with a general…

epidural hematoma, a type of head injury involving bleeding into the space between the skull and the dura mater, the outermost layer of the protective structures surrounding the brain. It can occur when a traumatic force applied to the head is sufficient to cause a deformity of the skull and damage

epidural hematoma, a type of head injury involving bleeding into the space between the skull and the dura mater, the outermost layer of the protective structures surrounding the brain. It can occur when a traumatic force applied to the head is sufficient to cause a deformity of the skull and damage

meninges: …two sheets separated by the epidural space, which is filled with veins. The outer of these two sheets constitutes the periosteum of the vertebral canal. The inner sheet is separated from the arachnoid by the narrow subdural space, which is filled with fluid. In a few places, the subdural space…

Russian literature: The Second South Slavic Influence: …Radonezh”) by Epifany Premudry (Epiphanius the Wise; d. between 1418 and 1422).

bivalve: Ecology and habitats: …has also been achieved by cementation, as, for example, in oysters.

trailing arbutus, (Epigaea repens), trailing plant of the heath family (Ericaceae), native to sandy or boggy, acid woodlands of eastern North America. It has oblong, hairy evergreen leaves 2–6 cm (0.75–2.5 inches) long. The highly fragrant white, pink, or rosy flowers have a five-lobed corolla (the

ancient Greek civilization: Formal relationships: …nationals of different states was epigamia, an arrangement by which the offspring of marriage were treated as citizens of the wife’s polis if the husband settled there; and so was the husband. Athens, for example, granted epigamia to Euboea as late as the 5th century, a time when Athenian citizenship…

angiosperm: Seedlings: In epigeous germination, the radicle emerges from the seed and the hypocotyl elongates, raising the cotyledons, epicotyl, and remains of the seed coat aboveground. The cotyledons may then expand and function photosynthetically as normal leaves (e.g., castor bean, Ricinus communis). When the cotyledons contain seed-storage products,…

loess: Origin and age.: Epigenesis is an accumulation of a mineral mass without loess properties, perhaps with a high silt and lime content, which under weathering and soil formation acquires loess properties and is transformed into loess. In syngenesis, the accumulation of a mineral mass that is mainly of…

biology: Preformation versus epigenesis: …in the proper environment; the epigenesis school believed that the egg is initially undifferentiated and that development occurs as a series of steps. Prominent supporters of the preformation doctrine, which was widely held until the 18th century, included Malpighi, Swammerdam, and Leeuwenhoek. In the 19th century, as criticism of preformation…

epigenetics: Epigenetic inheritance: It is clear that at least some epigenetic modifications are heritable, passed from parents to offspring in a phenomenon that is generally referred to as epigenetic inheritance, or passed down through multiple generations via transgenerational epigenetic inheritance. The mechanism by which epigenetic information…

epigenetics, the study of the chemical modification of specific genes or gene-associated proteins of an organism. Epigenetic modifications can define how the information in genes is expressed and used by cells. The term epigenetics came into general use in the early 1940s, when British embryologist

epigenetics: Impact of epigenetics on biomedicine: …researchers have recognized that the epigenome—chemical modification at the level of the genome—also influences a wide range of biomedical conditions. This new perception has opened the door to a deeper understanding of normal and abnormal biological processes and has offered the possibility of novel interventions that might prevent or ameliorate…

epigenomics, the study of chemical changes that regulate the expression, or use, of the entire collection of DNA molecules in an organism’s cells. This collection of genetic material is known as the organism’s genome. Genomes serve as dynamic blueprints, directly or indirectly enabling the

angiosperm: Seedlings: In epigeous germination, the radicle emerges from the seed and the hypocotyl elongates, raising the cotyledons, epicotyl, and remains of the seed coat aboveground. The cotyledons may then expand and function photosynthetically as normal leaves (e.g., castor bean, Ricinus communis). When the cotyledons contain seed-storage products,…

childhood disease and disorder: Respiratory disorders: …the larynx (voice box) or epiglottis (the plate of cartilage that shuts off the entrance into the larynx during the process of swallowing), most often caused by viral infection; it is encountered in infants and small children. Inflammation and swelling of the vocal cords lead to respiratory obstruction, particularly in…

croup: Bacterial croup: Bacterial croup, also called epiglottitis, is a more serious condition that historically was caused primarily by Haemophilus influenzae type B. However, a vaccine effective against H. influenzae—known as the Hib vaccine—has significantly reduced the occurrence of epiglottitis caused by this organism. Today epiglottitis is more often caused by Staphylococcus…

religious dress: Eastern Orthodox religious dress: The epigonation, or rhombus-shaped portion of silk hanging to below the right knee, is common both to bishops and archimandrites (head abbots).

Karl Leberecht Immermann: …forerunners in German literary history: Die Epigonen as a novel of the contemporary social scene and Der Oberhof as a realistic story of village life.

Seven Against Thebes: …of the dead Seven, the Epigoni, or second generation, had grown to manhood, Adrastus again attacked the city and occupied it after the Thebans had evacuated it by night. He died at Megara on the homeward journey.

amphioxus: …Amphioxus) and Epigonichthyes (also called Asymmetron)—with about two dozen species. The chordate features—the notochord (or stiffening rod), gill slits, and dorsal nerve cord—appear in the larvae and persist into adulthood.

cephalochordate: Classification: Family Epigonichthyidae Gonads on right side of body only; Epigonichthys. Assorted Referencesmajor reference

perciform: Annotated classification: Family Epigonidae (deepwater cardinal fishes) Marine, oceanic midwaters 1,000–1,200 metres (3,300–4,000 feet) deep. More than 6 infraorbital bones. About 6 genera, about 25 species. Family Moronidae (temperate basses) Eocene to present. 2 dorsal fins connected at their bases. Most species slim-looking basses; well-known food and game

epigram, originally an inscription suitable for carving on a monument, but since the time of the Greek Anthology (q.v.) applied to any brief and pithy verse, particularly if astringent and purporting to point a moral. By extension the term is also applied to any striking sentence in a novel, play,

Ernesto Cardenal: His early poems, collected in Epigramas (1961), denounce the senseless violence of the Somoza regime in Nicaragua, while others are love poems written with a fine sense of irony. La hora 0 (1960; Zero Hour, and Other Documentary Poems), a long documentary poem denouncing the effects of domestic tyranny and…

John Owen: Owen’s Epigrammata are divided into 12 books, of which the first 4 were published in 1606 and the rest at four different times. Owen frequently adapted the lines of his predecessors in Latin verse, and one such borrowing become celebrated as a quotation: “Tempora mutantur, nos…

textual criticism: Books transmitted in manuscript: , Epigrammata Bobiensia a Latin translation of Greek epigrams). (4) A text may be a religious or literary work that was respectfully treated by copyists and protected by an exegetical tradition (e.g., the Bible, the Latin poet Virgil); or a popular book that was exposed to…

Plato: Varia: The Epigrams are elegiac couplets attributed to Plato. Epigrams 1–3 are especially interesting: they may well be authentic, and if so they would give a glimpse into Plato’s personal affections. Correspondence purporting to be from Plato is collected as the Letters or Epistles; their authorship is…

Martial: Life and career: …appeared the 12 books of epigrams on which his renown deservedly rests. In ad 86 Books I and II of the Epigrams were published, and between 86 and 98, when Martial returned to Spain, new books of the Epigrams were issued at more or less yearly intervals. After 34 years…

Edgar Lee Masters: …1909 he was introduced to Epigrams from the Greek Anthology. Masters was seized by the idea of composing a similar series of free-verse epitaphs in the form of monologues. The result was Spoon River Anthology, in which the former inhabitants of Spoon River speak from the grave of their bitter,…

John XI Becchus: …Becchus’ principal works are his Epigraphai (“Collected Texts”), an anthology of patristic writings on the theology of the Holy Spirit; a tract on the peace and union of the ancient and new Roman Churches; and various polemical treatises proposing recognition of papal primacy.

epigraphy, the study of written matter recorded on hard or durable material. The term is derived from the Classical Greek epigraphein (“to write upon, incise”) and epigraphē (“inscription”). Because such media were exclusive or predominant in many of the earliest human civilizations, epigraphy is a

spider: Mating: The female genital structure, or epigynum, is a hardened plate on the underside of the abdomen in front of the gonopore. After the sperm are transferred into the epigynum, they move into receptacles (spermathecae) that connect to the oviducts. Eggs are fertilized as they pass through the oviducts and out…

angiosperm: The gynoecium: In epigynous flowers, the hypanthium is fused to the gynoecium, and the free parts of the sepals, petals, and stamens appear to be attached to the top of the gynoecium, as in the apple (Malus; Rosaceae); the ovary is inferior, and the petals, sepals, and stamens…

spider: Mating: The female genital structure, or epigynum, is a hardened plate on the underside of the abdomen in front of the gonopore. After the sperm are transferred into the epigynum, they move into receptacles (spermathecae) that connect to the oviducts. Eggs are fertilized as they pass through the oviducts and out…

horse: Evolution of the horse: …from the middle Eocene, and Epihippus, a genus from the late Eocene, resembled Eohippus in size and in the structure of the limbs. But the form of the cheek teeth—the four premolars and the three molars found in each half of both jaws—had changed somewhat. In Eohippus the premolars and…

ladybug: Two of these are the squash beetle (Epilachna borealis) and the Mexican bean beetle (E. varivestis).

ladybug: …beetle (Epilachna borealis) and the Mexican bean beetle (E. varivestis).

epilepsy, chronic neurological disorder characterized by sudden and recurrent seizures which are caused by an absence or excess of signaling of nerve cells in the brain. Seizures may include convulsions, lapses of consciousness, strange movements or sensations in parts of the body, odd behaviours,

hydrosphere: Lake waters: …the upper water layer (the epilimnion) and the lower water layer (the hypolimnion) of lakes. The starting point is photosynthesis, represented by the following reaction:

Epilobium, genus of about 200 plants, in the evening primrose family (Onagraceae), native to most temperate regions. It includes fireweed (q.v.; species E. angustifolium), which rapidly covers newly burned areas. The young parts of some species can be cooked and eaten as potherbs. The plants are

fireweed, (Epilobium angustifolium), perennial wildflower, in the evening primrose family (Onagraceae), abundant on newly clear and burned areas. Its spikes of whitish to magenta flowers, which grow up to 1.5 m (5 feet) high, can be a spectacular sight on prairies of the temperate zone. Like those

Epilobium: The hairy willow herb, or codling-and-cream (E. hirsutum), up to 2 m (6 feet) high, is similar to fireweed but has hairy leaves and stalks and notched flower petals; it is found in waste places in eastern North America. Rock fringe (E. obcordatum) is a prostrate…

Epilobium: E. montanum, with pale pink flowers, is found in temperate-zone woods.

Epilobium: E. nummularifolium, from New Zealand, has whitish flowers and brownish red leaves; it is grown in rock gardens for its attractive matlike growth. E. montanum, with pale pink flowers, is found in temperate-zone woods.

Luigi Pirandello: …1910 (when it was retitled La morsa) kept him from other than sporadic attempts at drama until the success of Così è (se vi pare) in 1917. This delay may have been fortunate for the development of his dramatic powers. L’epilogo does not greatly differ from other drama of its…

epilogue, a supplementary element in a literary work. The term epilogue carries slightly different meanings in nondramatic and dramatic works. In the former, the epilogue is the conclusion or final part that serves typically to round out or complete the design of the work. In this context it is

Alexander Pope: Life at Twickenham: …verse, republished as the “Epilogue to the Satires” (1738), where, as in “An Epistle to Dr. Arbuthnot,” Pope ingeniously combined a defense of his own career and character with a restatement of the satirist’s traditional apology. In these imitations and dialogues, Pope directed his attack upon the materialistic standards…

religious dress: Eastern Orthodox religious dress: The cuffs, or epimanikia, which fit over the sticharion, bear little or no resemblance to the maniple. The epitrachelion is the Orthodox equivalent of the stole, but it hangs straight instead of being crossed over the chest, as is the case with the stole in Western churches. On…

animal behaviour: Function: …however, animals engage in apparent altruism (that is, they exhibit behaviour that increases the fitness of other individuals by engaging in activities that decrease their own reproductive success). For example, American zoologist Paul Sherman found that female Belding’s ground squirrels (Spermophilus beldingi) give staccato whistles that warn nearby conspecifics of…

mollusk: Size range and diversity of structure: centimetres; and, among solenogasters, Epimenia reaches a length of 15 to 30 centimetres. Finally, gastropods of the family Entoconchidae, which are parasitic in echinoderm sea cucumbers, may reach a size of almost 1.3 metres. In contrast, there are also minute members, less than one millimetre (0.04 inch) in size,…

Epimenides was a Cretan seer, reputed author of religious and poetical writings, including a Theogony, Cretica, and other mystical works. Religious theories of an Orphic character were attributed to him as well. He conducted purificatory rites at Athens, according to Plato. Stories of his advanced

Johann Wolfgang von Goethe: Napoleonic period (1805–16) of Johann Wolfgang von Goethe: He obliged with Des Epimenides Erwachen (1815; “Epimenides Awakes”), but the play shows that his feelings about the great victory were ambiguous. He had to be pleased that the Treaty of Paris signed in 1815 provided for the works of art looted from Italy to be returned, but…

liar paradox, paradox derived from the statement attributed to the Cretan prophet Epimenides (6th century bce) that all Cretans are liars. If Epimenides’ statement is taken to imply that all statements made by Cretans are false, then, since Epimenides was a Cretan, his statement is false (i.e., not

Saturn: Orbital and rotational dynamics: Janus and Epimetheus are co-orbital moons—they share the same average orbit. Every few years they make a close approach, interacting gravitationally in such a way that one transmits angular momentum to the other, which forces the latter into a slightly higher orbit and the former into a…

Pandora: Zeus sent her to Epimetheus, who forgot the warning of his brother Prometheus and made Pandora his wife. She afterward opened the jar, from which the evils flew out over the earth. Hope alone remained inside, the lid having been shut down before she could escape. In a later…

homomorphism: …of H, is called an epimorphism. An especially important homomorphism is an isomorphism, in which the homomorphism from G to H is both one-to-one and onto. In this last case, G and H are essentially the same system and differ only in the names of their elements. Thus, homomorphisms are…

meat processing: Skeletal muscle structure: …of connective tissue called the epimysium. Individual muscles are divided into separate sections (called muscle bundles) by another connective tissue sheath known as the perimysium. Clusters of fat cells, small blood vessels (capillaries), and nerve branches are found in the region between muscle bundles. Muscle bundles are further divided into…

Épinal, town, capital of the Vosges département, Grand Est région, northeastern France, on the Moselle River, south-southeast of Nancy. The town, located on two arms of the Moselle, is divided into four parts. The town proper, known as the grande ville (“large town”), or vieille ville (“old town”),

Louise-Florence-Pétronille Tardieu d’Esclavelles, dame de la Live d’Épinay was a distinguished figure in advanced literary circles in 18th-century France. Though she wrote a good deal herself, she is more famous for her friendships with three of the outstanding French writers and thinkers of her

Épinay-sur-Seine, town, northern suburb of Paris, Seine-Saint-Denis département, Paris région, north-central France, on the Seine River. Épinay originated from a Gallic-Roman settlement called Spinogelum (Place of Thorns and Gorse), and in the Middle Ages it was the site of La Brache, a castle of

hind: …hinds are in the genus Epinephelus, which also includes many groupers. They are found in the Atlantic Ocean and Gulf of Mexico along the North American coast, with the exception of the red hind (E. guttatus), which ranges from the Carolinas to Brazil. The rock hind (E. adscensionis), ranging from…

grouper: …49 inches) long; and the rock hind (E. adscensionis), an Atlantic food species spotted with orange or red and up to 61 cm (24 inches) long.

hind: …61 cm (24 inches); the speckled hind (E. drummondhayi) of the coastal region of the southeastern United States is somewhat smaller, reaching a length of 46 cm (19 inches).

hind: …with the exception of the red hind (E. guttatus), which ranges from the Carolinas to Brazil. The rock hind (E. adscensionis), ranging from New England to the West Indies, may reach 61 cm (24 inches); the speckled hind (E. drummondhayi) of the coastal region of the southeastern United States is…

goliath grouper, (Epinephelus itajara), large sea bass (family Serranidae) found on the Atlantic and Pacific coasts of tropical America and in the eastern Atlantic Ocean. The species sometimes attains a length of 2.5 metres (8.2 feet) and a weight of about 455 kg (1,000 pounds). The adult is dull

goliath grouper: The related giant grouper (E. lanceolatus) found in the Pacific and Indian ocean basins may reach 2.7 metres (8.8 feet) in length.

grouper: …black, or Warsaw, grouper (E. nigritus, also classified as Hyporthodus nigritus), of the Atlantic, is another large species. Adult black groupers can grow to 2.3 metres (7.5 feet) in length and weigh nearly 200 kg (440 pounds). Grayish or brownish in colour, it is the only grouper with 10…

grouper: Some, such as the Nassau grouper (Epinephelus striatus), are noted for their ability to change from one to any of a number of other colour patterns. Also, in many species, such as the black and yellowfin groupers (Mycteroperca bonaci and M. venenosa, respectively), individuals inhabiting deeper waters are much…

epinephrine, hormone that is secreted mainly by the medulla of the adrenal glands and that functions primarily to increase cardiac output and to raise glucose levels in the blood. Epinephrine typically is released during acute stress, and its stimulatory effects fortify and prepare an individual

epinephrine autoinjector, device consisting of a syringe and a spring-loaded needle that is used for rapid administration of the hormone epinephrine (adrenaline). Epinephrine is most commonly administered with an autoinjector following the onset of anaphylaxis (a severe systemic and potentially

epinephrine tolerance test, assessment of the metabolism of liver glycogen by measuring the blood-sugar response to a standard dose of epinephrine (adrenalin). Epinephrine normally accelerates the conversion of liver glycogen (the conjugated, storage form of glucose) to blood glucose, and a

epinicion, lyric ode honouring a victor in one of the great Hellenic games. The epinicion was performed usually by a chorus, or on occasion by a solo singer, as part of the celebration on the victor’s triumphal return to his city; alternatively, a less elaborate form was offered on the site of his

epinicion, lyric ode honouring a victor in one of the great Hellenic games. The epinicion was performed usually by a chorus, or on occasion by a solo singer, as part of the celebration on the victor’s triumphal return to his city; alternatively, a less elaborate form was offered on the site of his

epinicion, lyric ode honouring a victor in one of the great Hellenic games. The epinicion was performed usually by a chorus, or on occasion by a solo singer, as part of the celebration on the victor’s triumphal return to his city; alternatively, a less elaborate form was offered on the site of his

epinicion, lyric ode honouring a victor in one of the great Hellenic games. The epinicion was performed usually by a chorus, or on occasion by a solo singer, as part of the celebration on the victor’s triumphal return to his city; alternatively, a less elaborate form was offered on the site of his

epinicion, lyric ode honouring a victor in one of the great Hellenic games. The epinicion was performed usually by a chorus, or on occasion by a solo singer, as part of the celebration on the victor’s triumphal return to his city; alternatively, a less elaborate form was offered on the site of his

helleborine: …two similar genera Cephalanthera and Epipactis (family Orchidaceae). The genus Cephalanthera has about 14 north temperate species, while Epipactis comprises about 21 species native to north temperate areas, tropical Africa, and Mexico. Plants of both genera usually have tall thin stems and crinkled leaves.

helleborine: Dune helleborine (E. dunensis) grows along the sandy coasts of Great Britain and northwestern Europe. Marsh helleborine (E. palustris) is found in marshes and wet places throughout Europe. Broad-leaved helleborine (E. helleborine) is a common species in Europe and temperate Asia and has been introduced…

helleborine: Broad-leaved helleborine (E. helleborine) is a common species in Europe and temperate Asia and has been introduced into the eastern United States. Its flowers are green, whitish green, or reddish purple, and its nectar contains trace amounts of naturally occurring oxycodone.

helleborine: Marsh helleborine (E. palustris) is found in marshes and wet places throughout Europe. Broad-leaved helleborine (E. helleborine) is a common species in Europe and temperate Asia and has been introduced into the eastern United States. Its flowers are green, whitish green, or reddish purple, and…

India: Mesolithic hunters: …and 10,000 bce represents the Epipaleolithic Stage, which may be considered to fall within the Mesolithic. The domestication of sheep and goats is thought to have begun in this region and period.

horizon: Epipedons are characterized by their colour, texture, structure, and content of organic matter and certain plant nutrients (e.g., calcium, phosphate). Another important concept is that of subsurface diagnostic horizons. These are characterized by the type of accumulated weathering products that they contain (e.g., clay, mixtures…

marine ecosystem: Geography, oceanography, and topography: …the neritic and oceanic waters—the epipelagic zone—is where photosynthesis occurs; it is roughly equivalent to the photic zone. Below this zone lie the mesopelagic, ranging between 200 and 1,000 metres, the bathypelagic, from 1,000 to 4,000 metres, and the abyssalpelagic, which encompasses the deepest parts of the oceans from 4,000…

fern: Ecology: Both epipetric (growing on rocks) and epiphytic ferns may show structural adaptations to dry habitats similar to those of some desert plants. These adaptive features include such specializations as hard tissues and thick texture; the surface cells, or epidermis, may be provided with a very thick…

Ḥamāh, city, central Syria, on the banks of the Orontes River. It was an important prehistoric settlement, becoming the kingdom of Hamath under the Aramaeans in the 11th century bce. It fell under Assyrian control in the 9th century bce and later passed under Persian, Macedonian, and Seleucid rule,

Ḥamāh, city, central Syria, on the banks of the Orontes River. It was an important prehistoric settlement, becoming the kingdom of Hamath under the Aramaeans in the 11th century bce. It fell under Assyrian control in the 9th century bce and later passed under Persian, Macedonian, and Seleucid rule,

Saint Epiphanius of Constantia ; feast day May 12) was a bishop noted in the history of the early Christian church for his struggle against beliefs he considered heretical. His chief target was the teachings of Origen, a major theologian in the Eastern church whom he considered more a Greek

Russian literature: The Second South Slavic Influence: …Radonezh”) by Epifany Premudry (Epiphanius the Wise; d. between 1418 and 1422).