Wild and domesticated mammals are so interlocked with our political and social history that it is impractical to attempt to assess the relationship in precise economic terms. Throughout our own evolution, for example, humans have depended on other mammals for food and clothing. Domestication of mammals helped to provide a source of protein for ever-increasing human populations and provided means of transportation and heavy work as well. Today, domesticated strains of the house mouse, European rabbit, guinea pig, hamster, gerbil, and other species provide much-needed laboratory subjects for the study of human-related physiology, psychology, and a variety of diseases from dental caries to cancer. The study of nonhuman primates (monkeys and apes) has opened broad new areas of research relevant to human welfare. The care of domestic and captive mammals is, of course, the basis for the practice of veterinary medicine.

Wild mammals are a major source of food in some parts of the world, and many different kinds, from fruit bats and armadillos to whales, are captured and eaten by various cultural groups. In addition, hunting, primarily for sport, of various rodents, lagomorphs, carnivores, and ungulates is a multibillion-dollar enterprise. In the United States alone, for example, it is estimated that more than two million deer are harvested annually by licensed hunters.

Geopolitically, the quest for marine mammals was responsible for the charting of a number of areas in both Arctic and Antarctic regions. The presence of terrestrial furbearers, particularly beavers and several species of mustelid carnivores (e.g., marten and fisher), was one of the principal motivations for the opening of the American West, Alaska, and the Siberian taiga. Ranch-raised animals such as the mink, fox, and chinchilla are also important to the fur industry, which directly and indirectly accounts for many millions of dollars in revenue each year in North America alone.

Aside from pelts and meat, special parts of some mammals regularly have been sought for their special attributes. Rhinoceros horn is used for concocting potions in eastern Asia; ivory from elephants and walruses is highly prized; and ambergris, a substance regurgitated by sperm whales, was once widely used as a base for perfumes.

Some mammals are directly detrimental to human activities. House rats and mice of Old World origin now occur virtually throughout the world and each year cause substantial damage and economic loss. Herbivorous mammals may eat or trample crops and compete with livestock for food, and native carnivores sometimes prey on domestic herds. Large sums are spent annually to control populations of “undesirable” wild mammals, a practice long deplored by conservationists. Not only do they have an impact on food resources, but mammals are also important reservoirs or agents of transmission of a variety of diseases that afflict man, such as plague, tularemia, yellow fever, rabies, leptospirosis, Lyme disease, hemorrhagic fevers such as Ebola, and Rocky Mountain spotted fever. The annual “economic debt” resulting from mammal-borne diseases that affect humans and domestic animals is incalculable.

Many large mammals have been extirpated entirely or exist today only in parks and zoos; others are in danger of extinction, and their plight is receiving increased attention from a number of conservation agencies. By the early 21st century, the International Union for Conservation of Nature (IUCN) reported that nearly one-quarter of all mammals are at risk of extinction. The single greatest threat to these mammals is the continued destruction of their habitat; however, many species are also aggressively hunted. The IUCN classifies each imperiled mammal into one of the following categories: near threatened, vulnerable, endangered, critically endangered, critically endangered and possibly extinct, or extinct in the wild (see IUCN Red List of Threatened Species).

One of the most noteworthy cases of direct extirpation by man is the Steller’s sea cow (Hydrodamalis gigas). These large (up to 10 metres, or 33 feet, long), inoffensive marine mammals evidently lived only along the coasts and shallow bays of the Komandor Islands in the Bering Sea. Discovered in 1741, they were easily killed by Russian sealers and traders for food, their meat being highly prized, and the last known live individual was taken in 1768.

Of final note is the aesthetic value of wild mammals and the relatively recent expense of considerable energy and resources to study and, if possible, conserve vanishing species, to set aside natural areas where native floral and faunal elements can exist in an otherwise highly agriculturalized or industrialized society, and to establish modern zoological parks and gardens. Such outdoor “laboratories” attract millions of visitors annually and will provide means by which present and future generations of humans can appreciate and study, in small measure at least, other kinds of mammals.