Acute canalicular (cholestatic) hepatitis
Acute canalicular (cholestatic) hepatitis is most commonly caused by certain drugs, such as psychopharmacologics, antibiotics, and anabolic steroids or, at times, by hepatitis viruses. The symptoms are generally those of biliary obstruction and include itching, jaundice, and light-coloured stools. Drug-induced cholestasis almost invariably disappears within days or weeks after exposure to the agent is discontinued. Acute congestive liver disease usually results from the sudden engorgement of the liver by fluids after congestive heart failure. The liver may enlarge and become tender. The levels of hepatocytic enzymes in the blood are often greatly increased, and recovery is rapid once the heart failure improves. Jaundice is uncommon in acute hepatic congestion.
Chronic active hepatitis
Chronic hepatitis is the result of unresolved acute injury and is associated with ongoing liver damage. The course of the disease is usually slow but relentlessly progressive. A milder form of chronic disease, called persistent hepatitis, does not appear to lead to progressive liver damage despite evidence of a continuing mild inflammation. These conditions may result from viral hepatitis, drug-induced hepatitis, autoimmune liver diseases (lupoid hepatitis), or congenital abnormalities. A prominent autoimmune liver disease is Wilson disease, which is caused by abnormal deposits of large amounts of copper in the liver. Granulomatous hepatitis, a condition in which localized areas of inflammation (granulomas) appear in a portion of the liver lobule, is a type of inflammatory disorder associated with many systemic diseases, including tuberculosis, sarcoidosis, schistosomiasis, and certain drug reactions. Granulomatous hepatitis rarely leads to serious interference with hepatic function, although it is often chronic.
Chronic viral hepatitis B and C can be treated with interferon. Cirrhosis of the liver, and occasionally liver cancer, usually result from a gradual loss of liver function. Chronic hepatitis that is the result of autoimmune disorders usually responds to the administration of immunosuppressive medications and adrenal corticosteroids, which moderate the inflammatory reaction.
Cirrhosis
The end result of many forms of chronic liver injury is cirrhosis, or scarring of liver tissue in response to previous acinar necrosis and irregular regeneration of liver nodules and bile ducts. Among the congenital disorders producing cirrhosis are Wilson disease, hemochromatosis (over-deposition of iron pigment), cystic fibrosis, biliary atresia (congenital absence of a part of the bile ducts), and alpha1-antitrypsin deficiency, or the congenital absence of a proteolytic enzyme inhibitor that results in the accumulation of abnormal forms of carbohydrate in hepatocytes. In the Western world, cirrhosis of the liver most commonly results from chronic heavy intake of alcohol. This type of cirrhosis is known as Laënnec, or portal, cirrhosis. Chronic viral hepatitis is probably the leading cause of cirrhosis in underdeveloped countries. Primary biliary cirrhosis, a geographically widespread, though uncommon, autoimmune inflammatory disease of bile ducts, is a disorder primarily affecting middle-aged and older women. The inflammation leads to necrosis and gradual disappearance of bile ducts over a period of one or more decades. Secondary biliary cirrhosis results from chronic obstruction or recurrent infection in the extrahepatic bile ducts caused by strictures, gallstones, or tumours. Infestation of the biliary tract with a liver fluke, Clonorchis sinensis, is a cause of secondary biliary cirrhosis in Asia. Cirrhosis occasionally is the result of chronic vascular congestion of the liver in persons with prolonged heart failure and in those with chronic obstruction of the hepatic veins caused by benign blood clots or metastatic cancer.
Symptoms of cirrhosis are usually absent during the early stages of the disease. Occasionally, cirrhosis is detected during a physical examination when an enlargement of the liver, spleen, or veins in the upper abdominal wall is found. More often, patients develop symptoms related either to the failure of the liver to perform its functions or to complications caused by the circulatory changes that a cirrhotic liver imposes on the venous blood flow from the intestinal tract (portal hypertension). Thus, common symptoms of cirrhosis include jaundice, resulting from reduced passage of conjugated bilirubin into the biliary tract; increased bleeding, from sequestration of blood platelets in a congested spleen; or deficient production of short-lived coagulation proteins by the liver. There may be certain changes in the skin, such as the appearance of small spiderlike vascular lesions on the hands, arms, or face, a marked reddening of portions of the palms, or enlargement of the breast in females or reduction in testicular size in males. These symptoms are believed to occur because of the liver’s inability to metabolize the female sex hormones normally produced by the body. The gradual accumulation of fluid in the abdominal cavity (ascites), sometimes accompanied by swelling of the ankles, is attributable to portal hypertension and to reduced hepatic production of albumin, while failure of the liver to metabolize amino acids and other products of protein digestion may lead to the state of confusion called hepatic encephalopathy. Loss of appetite, reduction of muscle mass, nausea, vomiting, abdominal pain, and weakness are other symptoms of hepatic cirrhosis. Diabetes in a patient with cirrhosis is frequently caused by hemochromatosis (excessive deposition of iron in tissues, especially in the liver and pancreas), since iron deposits compromise the production of insulin by the islets of Langerhans in the pancreas. Severe spastic disorders of the muscles in the limbs, head, and face suggest the presence of Wilson disease, especially if there is a family history, since the copper deposits characteristic of that disorder are toxic to the liver and to structures in the base of the brain. A history of chronic lung infections or of progressive obstructive lung disease may be present in patients with cystic fibrosis or a deficiency of alpha1-antitrypsin.
A diagnosis of cirrhosis is confirmed by blood tests that show an elevated concentration of hepatocytic enzymes, reduced levels of coagulation proteins, elevated levels of bilirubin, and, most important, reduced amounts of serum albumin (a major protein of human blood plasma) and increases in serum globulin (a specific group of proteins found in blood plasma and including immunoglobulins). Although other tests may also be abnormal in patients with acute liver disease, serum albumin levels are usually not reduced in the acute stage of the disease because that protein is rather long-lived (up to one month) and levels do not decrease until the liver disease becomes chronic. Elevated levels of serum iron or copper support a diagnosis of hemochromatosis or Wilson disease, respectively, while a positive test for serum antibodies to cellular mitochondria is associated almost solely with primary biliary cirrhosis. The presence of HBV surface antigen or of delta agent suggests viral cirrhosis. A biopsy of the liver is the most valuable diagnostic test, since this procedure makes available an actual specimen of liver tissue for microscopic examination. Treatment of cirrhosis of the liver never results in a completely normal organ, since the process of scarring and nodular regeneration is permanent. The process itself, however, can be prevented or its progress halted by managing the precipitating factors of the disease.
Complications of advanced liver disease
Hepatic encephalopathy
Hepatic encephalopathy refers to changes in the brain that occur in patients with advanced acute or chronic liver disease. If liver cells are damaged, certain substances that are normally cleansed from the blood by the healthy liver are not removed. These products of cell metabolism are primarily nitrogenous substances derived from protein, especially ammonia, or possibly certain short-chain fatty acids. They pass to the brain where they damage functioning nervous tissue or subvert the actions of neurotransmitters, chemical messengers that carry impulses from one brain cell to another. In acute cases, the brain becomes swollen to the point where normal breathing may cease. Chronic exposure can lead to destruction of nerve cells with replacement by scar tissue (gliosis). A patient with chronic hepatic encephalopathy may develop progressive loss of memory, disorientation, and muscular tremors, leading to a form of chronic dementia. The ingestion of protein invariably aggravates these symptoms. Patients with gastrointestinal bleeding, infection, kidney failure, and constipation and those who are taking certain medications are all at risk of worsened episodes of hepatic encephalopathy.
The treatment of hepatic encephalopathy involves, first, the removal of all drugs that require detoxification in the liver and, second, the reduction of protein intake. Ammonia is a potentially harmful by-product of digestion, and its concentration in the blood can be lowered either through the reduction of intestinal bacteria by administration of enteric antibiotics, which reduce the production of ammonia in the colon or by administration of lactulose, a nonabsorbable carbohydrate whose by-products make the contents of the colon more acidic, creating an environment that reduces the diffusion of ammonia from the intestinal lumen to the portal blood vessels.
Portal hypertension
Portal hypertension is the increased pressure in the portal vein and its tributaries. It is the result of impediments to venous flow into the liver, and is brought about by the scarring characteristic of the cirrhotic process. The increased pressure causes feeders of the portal vein to distend markedly, producing varices, or dilations of the veins. When varices are located in superficial tissues, they may rupture and bleed profusely. Varices most commonly occur in the lower esophagus, the stomach, and the perianal region. Esophageal varices are likely to bleed most heavily, and, because of the reduced blood flow in the liver that results and the large amount of protein contained in the blood that is shed into the intestines, profuse bleeding from esophageal varices is frequently associated with the onset of hepatic encephalopathy or coma. Because of their location at the lower end of the esophagus or the upper portion of the stomach, bleeding from varices is often difficult to control. Bleeding may stop spontaneously, but it is likely to recur. Considerable success in stemming such hemorrhage and preventing its recurrence has been achieved by using rubber bands to block the blood supply to each varix or by the injection of sclerosing (hardening) agents into varices during endoscopic visualization. If variceal bleeding persists and if the patient can withstand a long and complex operative procedure, surgical formation of a shunt, or artificial passageway, from the portal vein or one of its feeders to a systemic abdominal vein, such as the vena cava or the left renal vein, or from the hepatic vein to the portal vein may be performed.
Ascites
The accumulation of fluid in the abdominal cavity, or ascites, is related to portal hypertension, significant reduction in serum albumin, and renal retention of sodium. When albumin levels in the blood are lower than normal, there is a marked reduction in the force that holds plasma water within the blood vessels and normally resists the effects of the intravascular pressure. The resulting increase in intravascular pressure, coupled with the increased internal pressure caused by the portal venous obstruction in the liver, leads to massive losses of plasma water into the abdominal cavity. The associated reduction of blood flow to the kidneys causes increased elaboration of the hormone aldosterone, which, in turn, causes the retention of sodium and water and a reduction in urinary output. In addition, because the movement of intestinal lymph into the liver is blocked by the cirrhotic process in the liver, the backflow of this fluid into the abdominal cavity is greatly increased. The volume of abdominal ascites in adults with cirrhosis may reach levels as great as 10 to 12 litres (11 to 13 quarts). Ascitic fluid may accumulate in the scrotum and in the chest cavity, where its presence, combined with the upward pressure on the diaphragm from the abdominal fluid, may severely affect breathing. Appetite also is often reduced by the abdominal distention.
The treatment of cirrhotic ascites begins with the removal of enough fluid directly from the abdomen by needle puncture to ease discomfort and breathing. Patients are placed on diets low in salt (sodium chloride), and they are given diuretic drugs to increase the output of water by the kidneys. If these measures do not control massive ascites, ascites can be drained internally into the general venous blood system by running a plastic tube from the abdominal cavity, under the skin of the chest, into the right internal jugular vein of the neck (peritoneovenous shunt of LeVeen) or from the hepatic vein to the portal vein.
Hepatorenal syndrome
Hepatorenal syndrome, a progressive reduction in kidney function that often occurs in persons with advanced acute or chronic liver disease, probably results from an inadequate flow of blood through the cortical (outer) portions of the kidneys, where most removal of waste products occurs. In some instances, hepatorenal syndrome is caused by marked reductions in blood volume that result from a low concentration of water in the blood. Hemorrhages also can reduce kidney function by leading to damage of renal tubules. Finally, with advanced hepatocytic dysfunction, a spasm of blood vessels in the renal cortex can occur, which results in progressive failure in kidney function and often leads to death. The kidneys themselves are frequently undamaged structurally. Treatment of patients with volume depletion and tubular damage often may lead to significant improvement in kidney function. Dialysis may improve symptoms.
Tumours
Liver cancer, usually in hepatocytes and less frequently in cells of bile duct origin, is rare in the Western world and is almost always associated with active cirrhosis, particularly the form found in patients with chronic hepatitis. The survival rate from liver cancer is low. In certain underdeveloped countries, especially in Africa, the incidence of this malignancy is high and is a major cause of death in the population. Most of these cases appear to stem from the prevalence of chronic viral hepatitis or the chronic presence of viruses in the blood (viremia) caused by hepatitis B. Long exposure to certain environmental poisons, such as vinyl chloride or carbon tetrachloride, has also been shown to lead to hepatic cancer.
Cancers arising elsewhere in the body, particularly in abdominal organs, lungs, and lymphoid tissue, commonly lead to metastatic cancer in the liver and are by far the most frequent type of hepatic malignancy. Usually, when such metastases are found, the primary tumour has advanced beyond the stage where it can be removed surgically.
Various benign types of tumours and cysts arise from certain components of the liver, such as the hepatocytes (adenomas) or blood vessels (hemangiomas). While the cause of these lesions is not always clear, hepatic adenomas are associated with the prolonged use of female sex hormones (estrogens). Symptoms of benign tumours depend mainly on their size and their position in relation to the surface of the liver. If they enlarge significantly, patients may experience pain or sensations of heaviness in the upper abdomen. When benign tumours are located close to the surface of the liver, they may rupture through the capsule and bleed freely into the abdominal cavity. Surgery is then required.
Benign cysts (tissue swellings filled with fluid) in the liver may occur as congenital defects or as the result of infections from infestation of the dog tapeworm (Echinococcus granulosus). Abscesses on the liver result from the spread of infection from the biliary tract or from other parts of the body, especially the appendix and the pelvic organs. Specific liver abscesses also result from infections with the intestinal parasite Entamoeba histolytica. Abscesses usually respond well to treatment with specific antibiotics, although surgical drainage is required in some cases.
