Electrical stimulation in cats of regions in and related to the anterior part of the hypothalamus can induce the behavior of expelling or retaining urine and feces. When electrodes planted in these regions are stimulated by radio waves, the cat stops whatever it is doing and behaves as though it is going to urinate or defecate. It goes through its usual behavior of digging a hole, squatting, and assuming the correct posture, and then it passes urine or feces. At the end, it even goes through its customary ritual of hiding its excreta.

Eating and drinking

The eating and drinking centers are in the lateral and ventromedial regions of the hypothalamus, although such basic aspects of living concern most of the brain. If the lateral region is experimentally destroyed, the animal consumes less food or stops eating altogether; if the ventromedial region is destroyed, it eats enormously. When neurons of the lateral region are electrically stimulated, a monkey eats, and when those of the ventromedial area are stimulated, the monkey stops eating. There is an increase in the activity of these neurons when the monkey looks at food, but only when it is hungry. Receptors in the lateral region monitor blood glucose and are stimulated only when blood glucose is low; satiety stops their response.

Hunger does not depend only on these glucose receptors. Severe hunger is associated with contractions of the stomach, which are felt almost as a sensation of pain. Yet neither is this an essential mechanism for feeling hungry, as patients who have had total removal of the stomach still feel hunger. In experiments in rats, it is found that stress may make the animal either increase or reduce the amount it eats. This is probably the same in humans.

When certain neurons in the same regions of the hypothalamus are experimentally destroyed, animals lose the urge to drink, although they continue to eat normally. Stimulation of these neurons causes them to drink excessively. Control of drinking depends on osmoreceptors located throughout the hypothalamus. When receptors detect a minimal increase in the concentration of dissolved substances in the extracellular fluid, which indicates cellular dehydration, the sensation of thirst occurs. A less-important contributor to the sensation of thirst is a reduction in blood volume. Dryness of the mouth can also be a component of thirst, noted by receptors in the mucous membrane. The feeling of having drunk enough depends not only on the hypothalamic neurons but also on receptors in the wall of the stomach, which report when the stomach is full.

Both glucose receptors and osmoreceptors are sensitive to the temperature of the passing blood. When the temperature starts to rise, one feels thirsty but not hungry; cooling the blood makes one feel hungry.

Temperature regulation

To maintain homeostasis, heat production and heat loss must be balanced. This is achieved by both the somatomotor and sympathetic systems. The obvious behavioral way of keeping warm or cool is by moving into a correct environment. The posture of the body is also used to balance heat production and heat loss. When one is hot, the body stretches out—in physiological terms, extends—thus presenting a large surface to the ambient air and losing heat. When one is cold, the body curls itself up—in physiological terms, flexes—thus presenting the smallest area to the ambient temperature.

The sympathetic system is the most important part of the nervous system for controlling body temperature. On a long-term basis, when the climate is cold, the sympathetic system produces heat by its control of certain fat cells called brown adipose tissue. From these cells, fatty acids are released, and heat is produced by their chemical breakdown.

Body temperature fluctuates regularly within 24 hours; this is a type of circadian rhythm (see below). It also fluctuates in rhythm according to the menstrual cycle. During fever, the body temperature is set at a higher point than normal.

Reward and punishment

In a fundamental discovery made in 1954, Canadian researchers James Olds and Peter Milner found that stimulation of certain regions of the brain of the rat acted as a reward in teaching the animals to run mazes and solve problems. The conclusion from such experiments is that stimulation gives the animals pleasure. The discovery has also been confirmed in humans. These regions are called pleasure, or reward, centers. One important center is in the septal region, and there are reward centers in the hypothalamus and in the temporal lobes of the cerebral hemispheres as well. When the septal region is stimulated in conscious patients undergoing neurosurgery, they experience feelings of pleasure, optimism, euphoria, and happiness.

Regions of the brain also clearly cause rats distress when electrically stimulated; these are called aversive centers. However, the existence of an aversive center is less certain than that of a reward center. Electrodes stimulating neurons or neural pathways may cause an animal to have pain, anxiety, fear, or any unpleasant feeling or emotion. These pathways are not necessarily centers that provide punishment in the sense that a reward center provides pleasure. Therefore, it is not definitely known that connections to aversive centers punish the animal for biologically wrong behavior, but it is thought that correct behavior is rewarded by pleasure provided by neurons of the brain.