The greatest tapestries of the 15th century were produced in the Flemish cities of Arras, Tournai, and Brussels. In the first half of the century it was Arras that particularly prospered under the patronage of the dukes of Burgundy. Duke Philip the Good (1396–1467) had a specially designed building erected in the city to allow for better conservation of his tapestry collection. Between 1423 and 1467 no fewer than 59 master tapestry weavers were working in Arras, but following the French siege of the city in 1477 under King Louis XI the industry declined. After approximately 1530 it was no longer active. While the importance of Arras waned, that of Tournai and eventually Brussels waxed—their tapestries becoming the most sought after in the late 15th century. Local identification marks did not become general until the 16th century, and continual intercourse between the various medieval centres of tapestry making, particularly Arras and Tournai, adds to the difficulty of determining where individual tapestries were made. Despite the prestige of Arras workmanship, it is ironic that only one set of tapestries dating from 1402 is inscribed with the actual name. Large fragments showing scenes from the lives of St. Piat and St. Eleutherius survive in the cathedral of Tournai, for which they were commissioned. The imagery of these tapestries, like that of most Gothic hangings, was closely related to the styles of painting current at the time. Other important examples of supposed Arras tapestries inspired by Franco-Flemish book miniatures or paintings on wood panels include the early 15th-century tapestry of The Annunciation, which was probably woven after a cartoon by Melchior Broederlam (active 1381–c. 1409), and the Court Scenes, related to the Très Riches Heures du duc de Berry illuminated by the Limbourg brothers (active early 15th century).

Whether a tapestry is an Arras or not is usually determined by comparison with the History of St. Piat and St. Eleuthère. One of the finest works so attributed is the early 14th-century fragment from the set in the Museo Civico at Padua, Italy, illustrating the Geste of Jourdain de Blaye, a medieval chivalric story adapted from the ancient Greco-Roman romance Apollonius of Tyre.

The craft, practiced since the end of the 13th century at Tournai, proved so prosperous that in 1398 a regulation concerning production was published. It is the oldest known ordinance regulating the craft of tapestry weaving. Among partially surviving tapestries ordered in the late 15th century by the court of Burgundy were two sets produced by the weaver and tapestry merchant Pasquier Grenier (died 1493) for Philip the Good. One set, The Story of Alexander, was purchased in 1459, and the other, The Knight of the Swan, was bought in 1462.

Cited by many scholars as an example of mid-15th-century Tournai weaving under the influence of Arras are the four renowned tapestries of The Hunts of the Dukes of Devonshire. Typical of the developed late Gothic Tournai style are the compacted vertical compositions of The Story of Strong King Clovis (mid-15th century) and The Story of Caesar (c. 1465–70). Many of the attributed Tournai weavings are heavily outlined and have a solemnity that contrasts to the more fanciful nature of Arras weavings. A sense of monumentality is created by the immense size of many of these supposed Tournai weavings and by the way the vast surfaces are densely filled with superimposed imagery.

A producer of tapestry since the 14th century, in the 15th century Brussels vied with Arras and Tournai. By mid-century, Brussels was noted for its highly skilled reproductions of religious paintings by Flemish masters of late Gothic realism, such as in the tapestry of The Adoration of the Magi. These panels were called “altarpiece tapestries” because they were usually intended for churches or private chapels, where they either were used as an altar cloth or antependium or were hung behind the altar as an altarpiece or fabric retable. In scale, altarpiece tapestries approximated the dimensions of the painting they copied and were, therefore, much smaller in size than the muralesque wall hangings of Arras and Tournai. Silk was commonly used to obtain the greater degree of naturalistic detail essential in reproducing a painting.

In the late 15th and early 16th centuries, Brussels also became famous for its production of tapis d’or, or “golden carpets,” so called because of the profuse use of gold threads. Examples such as The Triumph of Christ, popularly known as the Mazarin Tapestry (c. 1500), are characterized by their richness of effect.

Perhaps the best-known late Gothic hangings were the fanciful tapestries usually referred to as millefleurs (“thousand flowers”). A red or dark-blue ground strewn with flora and fauna sometimes serves as a setting for heraldic devices such as in the late 15th-century tapestry with the coat of arms of Philip the Good or acts as a background for scenes of the chivalric aristocratic life during the late Middle Ages, such as in The Hunt of the Unicorn or The Lady and the Unicorn. The origin of millefleurs tapestries is disputed, but it is thought that they were woven in the Flemish workshops of Brussels and Bruges and by itinerant weavers in the Loire Valley of France.

Itinerant Flemish and French weavers, setting up their looms in cities where there was temporary employment, carried tapestry weaving to Italy as early as the 15th century. Before the 16th century, however, most tapestries were bought in France and Flanders. Small workshops attached to the courts of various Italian nobles sporadically appeared for brief periods in Siena, Brescia, Todi, Perugia, Urbino, Mantua, Modena, Genoa, and Ferrara. The only one of importance was the Flemish-directed workshop of Ferrara, established around 1445 by the duke Lionello d’Este, who commissioned the famous Ferrarese early Renaissance painter Cosmè Tura (c. 1430–95) to make cartoons for his weavers.