Tumours within the spinal cord are called intrinsic, those outside the cord but compressing it are called extrinsic. Intrinsic tumours include ependymomas and astrocytomas, which are malignant, and angiomas and cysts, which are benign. Cancer of the breast, lung, kidney, or prostate gland can cause extrinsic tumours of the spinal cord. Other tumours arising outside the cord include lymphomas, lipomas, neurofibromas, meningiomas, and chordomas. All of these can cause spinal nerve irritation, with pain and tingling, at the level of the tumour. Diagnosis of a tumour is confirmed by myelography, usually with computed tomography (CT) scanning or magnetic resonance imaging (MRI). Raised protein levels or malignant cells in the cerebrospinal fluid may also confirm a tumour. Surgery and radiation therapy are the principal treatments.

Subacute combined degeneration

Subacute combined degeneration, which results from a vitamin B₁₂ deficiency, causes demyelination of the corticospinal and the dorsal columns. Much of the damage is to the large dorsal-root ganglion neurons; the peripheral nerve fibres also demyelinate, so that peripheral neuropathy also occurs. Symptoms include tingling, numbness, weakness, mental disturbances, and vision changes. Treatment with vitamin B₁₂ may lead to improvement.

Vascular disease

Diseases of the blood vessels are uncommon in the spinal cord. When blockages of vessels do occur, causes include severe atherothrombotic disease of the aorta, aortic or thoracic surgery, bleeding from an arteriovenous malformation, or arterial compression by a tumour or prolapsed disk.

Damage to the anterior three-quarters of the cord is common because this area is supplied by only the ventral spinal artery. The dorsal columns and the dorsal-root entry zone usually escape damage because they are supplied by three or more dorsal spinal arteries.

Radiation therapy for certain cancers may cause a slow but progressive deterioration of the roots and tracts at the irradiated level of the cord. Myelopathy often leads to spastic weakness of the legs and to less obvious sensory changes.

Syringomyelia

Syringomyelia is frequently associated with obstructions of the roof foramina, or openings, of the fourth ventricle of the brain. Increased pressure of the cerebrospinal fluid enlarges the canal and ultimately causes a cavity, or syrinx, to branch out from the spinal canal and enlarge over years. As a result, sensory fibres, traveling from the dorsal-root entry zone to the opposite spinothalamic tract and to ventral-horn neurons at the same level, are interrupted. In addition, compression of the corticospinal tracts occurs. Interruption of the dorsal-root–ventral-horn connection, which mediates reflex activity, results in loss of stretch reflexes and atrophy of some muscles innervated at that level. Interruption of the spinothalamic fibres, which transmit sensory impulses from both sides of the body to the thalamus, causes a loss of light touch, temperature, and pain sensations, as well as signs of an upper motor neuron lesion below the level of the cavity. Some perception, such as position sense, is retained. This is an example of dissociated sensory loss, which is also found in some brainstem lesions, transection of half of the spinal cord, and certain peripheral neuropathies.

Diagnosis of syringomyelia is determined by X ray, by CT scanning combined with myelography, or by MRI. Surgical drainage of the cavity, to prevent pressure from distending it further, may result in improvement.

Demyelinating disease

Demyelinating diseases frequently affect the spinal cord, particularly the corticospinal tracts and dorsal columns. The only features of Devic disease, a variant of multiple sclerosis, are a band of spinal cord inflammation and demyelination and optic nerve involvement.

Myoclonus

Brief, involuntary jerks of the trunk and of the limbs may occur in spinal myoclonus. Many diffuse, metabolic, or local structural causes of myoclonus are possible, and the disease commonly originates in the brainstem or in the cerebral hemispheres.

Olfactory nerve

Damage to the olfactory nerve can occur from a head injury, local nasal disease, or pressure from a tumour and may result in reduced sensitivity to smell or a complete loss (anosmia) on the side supplied by the nerve. Damage to the nerve may also result in a loss of flavour perception. Hallucinations of smell may occur in brain disorders such as epilepsy, with the presence of a tumour, or in depressive illnesses.