The region from the Bering Strait northward and east to the Mackenzie River was untouched by Russians, but after the mid-19th century it was visited by great numbers of European and Euro-American whalers, who imported both disease and alcohol; the Indigenous population declined by two-thirds or more between 1850 and 1910. In far northern Canada the impact was lessened somewhat, for contact was limited and the thinly distributed populations more easily avoided the spread of disease. Nevertheless, European whalers active in Hudson Bay and elsewhere were a source of disease and disruption that resulted in a significant decline in Indigenous population in the 19th century.

Intensive whaling, and later the hunting of walruses, depleted some of the major food sources of far northern communities and in some cases created localized hardship. However, whalers often recognized the technical skills of the northern Yupiit and the Inuit and arranged for various kinds of partnership; a Euro-American might reside with a local family for a winter, gaining food, shelter, and company while the family would gain labour-saving technology, such as metal knives, steel needles, and rifles.

Widespread difficulties arose with the imposition of assimilationist policies by the United States and Canada and later, after the discovery of gold, oil, and mineral resources in the region. By the late 19th century, church-sponsored experiments in reindeer herding were promoting assimilation in northern Alaska. These ventures generally failed due to their incompatibility with the local culture; people were accustomed to moving widely across the landscape but also had the habit of returning frequently to their home communities, a practice that quickly caused overgrazing near settlements. In addition, Euro-American entrepreneurs generally had enough capital to crowd out Indigenous reindeer operations. Gold strikes on Canada’s Klondike River in 1896 and near Nome, Alaska, in 1898 shifted attention away from Indigenous economic development, incidentally providing many northern Alaskan Natives with a welcome opportunity to return to traditional modes of subsistence.

As in western and southwestern Alaska, the northern parts of Alaska and Canada saw an increase in military facilities during and after World War II. By the 1950s and ’60s, concerns about environmental degradation and land seizures caused Alaskan Natives to file lawsuits to halt the development of oil and other resources. These suits eventually led to the Alaska Native Claims Settlement Act of 1971, in which the United States agreed to provide to Alaskan Natives some $962.5 million and 44 million acres of land, all to be administered through Indigenous-run corporations. For administrative purposes and to encourage local development, the state was divided among 12 regional Indigenous corporations (seven of them Inuit or Yupiit, one Unangax, and the rest Native American (First Nations), each including a series of village corporations in which individual Indigenous persons were sole shareholders. A 13th corporation serves Alaskan Natives who reside outside the state. The corporations have promoted housing, local schools, satellite communications facilities, medical facilities, and programs directed at alcohol abuse and have provided a training ground for Indigenous politicians active in state government, where they represent an increasingly sophisticated Indigenous citizenry.

Canada did not seek direct rule over the northern coastal region until the early 20th century, and the Canadian Inuit have had the same opportunities to vote and hold office as other Canadians only since about 1960—a time that coincides with the creation of increasingly stable settlements, the extension of social welfare, a decline in the importance of the traditional hunting economy, and the beginnings of Indigenous organizations that seek the recognition of the Inuit as a distinct people with rights of self-governance and to lands and traditional culture.

Canada’s Inuit proved quite adept at effecting political change. In the mid-1970s the province of Quebec took from the dominion government all political responsibility for relationships with Inuit residing there; Inuit communities soon organized into village corporations with defined rights to land and resources. At about the same time, the Northwest Territories elected people of Indigenous descent to a majority of the 15 seats then in the territorial legislative assembly; in 1979 the first Inuit was elected to one of the two Northwest Territories seats in the national House of Commons. A proposal to divide the Northwest Territories into two parts, the eastern to include the major Inuit territory, was submitted to a plebiscite in 1982. The proposal won heavily in the east but only narrowly overall. It eventually passed, and what had been the eastern part of the Northwest Territories became the territory of Nunavut in 1999.